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( Revision No. We can send by Fedex, by ship or by plane according to international rules. Learn about FMC's industry leading goal of net-zero emissions by 2035. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. (Microcrystalline Cellulose Market Pr. Revision No. CAS #: 9004-34-6 . Product Name: Microcrystalline Cellulose E460 1.2. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.)
They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. 6 0 obj
In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. Wu, K. Zuurman, H.W. <<
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Are you looking for information about products and services by region? Avicel PC 611 Microcrystalline Cellulose. It is available in different grades and particle sizes. Terms and Conditions Compliance Solutions Industries About 3E News & Events . EINECS #: 232-674-9 1.7. cas:9000-11-7 msds Carboxymethyl cellulose. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0
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Watch Now. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. gac74
[#B6`Wnw7 Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . MSDS Ref. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Molecular weight: Not Applicable 1.5. endobj
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Some substance identifiers may have been claimed confidential, or may . msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. EMCOCEL 90 M. 130. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Trademarks: Avicel PH-102. Performing this action will revert the following features to their default settings: Hooray! SUBSTANCE IDENTIFICATION 1.1. Cellulose microcrystalline. %PDF-1.4
Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Van Veen, G.K. Bolhuis, Y.S. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. No. Gloves, eye protection and a dust mask should be used. Microcrystalline Cellulose Side Effects. 102331. Remove . stream
Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. If you are already a ChemPoint customer then sign up for access to our online ordering website. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. l~5C
AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. ChemicalBook. The most. In 1964 FMC, Corporation . It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. Microcrystalline cellulose is a commonly used excipient in the . >>
The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. : CL-611NF Date Approved: 01/13/2010. 6 Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Doses up to 30 g per day appear to be . Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. common form is used in vitamin supplements or tablets. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. endstream
(&E. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. FMC Corporation. 1 0 obj
0.25 - 0.37. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER
FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information)
FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. The aqueous solution to barrier membrane coating. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. However, it yields non-digestible fibre. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. JFIF ` ` ZExif MM * J Q Q Q C
Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. Page 1 of 8. Go to Investor Relations. <>
Microcrystalline Cellulose / Avicel PH-102. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. In extrusion-spheronisation, it is the excipient of choice. cas:9032-51-3 msds CELLULOSE PAB. The figure below illustrates the structural organisation of cellulose within plants. 1. stream No. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. Microcrystalline Cellulose. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C
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g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Buy Chemicals. AVICEL RC 581. Report Category. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. It is, however, a good source of fibre. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine <>
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?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Instead, they obtained a stable colloidal suspension. PDF (2.77 mb) 2021 FMC Sustainability Report. ( SUBSTANCE IDENTIFICATION 1.1. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA
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cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. CAS No. }o]X4]. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. We know that our customers need to provide reliable and consistent products to their patients. Chemical Formula: (C6H10O5)n 1.4. Production of Pharmaceutical Grade Microcrystalline Cellulose. Microcrystalline Cellulose; Cellulose; Functions. Avicel Microcrystalline Cellulose: Chemical Identifiers. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . CAS 9004-34-6. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . ( Superior Performance: Provides excellent water uptake and rapid swelling . Molecular Weight null. Quantity: 1 700 kgs. undefined. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Cellulose microcrystalline for column chromatography. q9;v80 vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@
qaj/QU<5OrVMfl{pL? MSDS Ref. Your file is uploaded and ready to be published. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. <>
This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. Meet our leadership team. SDS. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. q9;v80q>jZ Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Apply today! Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. 51395-75-6 Avicel RC 591. %PDF-1.4
It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& 4 0 obj
The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >>
You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. MATERIAL SAFETY DATA SHEET Version: 1.0 1. It is a white, free-flowing powder. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4(
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%QL((((((((((((((((((((((((((((((((((((((((P3NhC Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . 9,LL!z Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm 8 0 obj (1962). Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Millipore. 0.25 - 0.37. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. Watch Now. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . 2021 Annual Report. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed.
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